SH2db - PIK3R1 protein entry

Protein	Domain	N-term	bA	bAaA	aA	aAbB	bB	bBbC	bC	bCbD	bD	bDbE	bE	bEbF	bF	bFaB	aB	C-term
PIK3R1	N-terminal	P	P	K	P	T	T	V	A	N	N	G	M	N	N	N	M	S	L	Q	D	A	E	W	Y	W	G	D	I	S	R	E	E	V	N	E	K	L	R	D	T	A	D	G	T	F	L	V	R	D	A	S	T	K	M	H	G	D	Y	T	L	T	L
PIK3R1	C-terminal	N	T	E	D	Q	Y	S	L	V	E	D	D	E	D	L	P	H	H	D	E	K	T	W	N	V	G	S	S	N	R	N	K	A	E	N	L	L	R	G	K	R	D	G	T	F	L	V	R	E	S	S	K	Q	G	-	-	C	Y	A	C	S	V

Structures


PDB	Type	Resolution	Domains	Chains	Publication date	Authors	Reference
P27986-AF	Alphafold	-	N-terminal C-terminal	A	2022-06-01	-	-
1H9O	X-ray diffraction	1.790	C-terminal	A	2001-03-19	Pauptit R.A., Dennis C.A. ... Rowsell S., Murshudov G.N.	10.1107/S0907444901012434
1PIC	Solution NMR	None	C-terminal	A	1997-09-17	Breeze A.L., Kara B.V. ... Best J.R., Cartlidge S.A.
5AUL	X-ray diffraction	1.100	C-terminal	A	2016-05-25	Inaba S., Numoto N. ... Ito N., Oda M.	10.1074/jbc.M116.755173
4JPS	X-ray diffraction	2.200	N-terminal	B	2014-04-02	Furet P., Guagnano V. ... Fabbro D., Caravatti G.	10.1016/j.bmcl.2013.05.007
2IUG	X-ray diffraction	1.890	N-terminal	A	2006-06-06	Nolte R.T., Eck M.J. ... Shoelson S.E., Harrison S.C.	10.1038/NSB0496-364
2IUH	X-ray diffraction	2.000	N-terminal	A	2006-06-06	Nolte R.T., Eck M.J. ... Shoelson S.E., Harrison S.C.	10.1038/NSB0496-364
2IUI	X-ray diffraction	2.400	N-terminal	A B	2006-06-06	Nolte R.T., Eck M.J. ... Shoelson S.E., Harrison S.C.	10.1038/NSB0496-364
3HHM	X-ray diffraction	2.800	N-terminal	B	2009-09-29	Mandelker D., Gabelli S.B. ... Vogelstein B., Amzel L.M.	10.1073/pnas.0908444106
3HIZ	X-ray diffraction	3.300	N-terminal	B	2009-09-29	Mandelker D., Gabelli S.B. ... Vogelstein B., Amzel L.M.	10.1073/pnas.0908444106
4L1B	X-ray diffraction	2.586	N-terminal	B	2014-01-01	Zhao Y., Zhang X. ... Meng L., Zhang J.	10.1021/ml400378e
4L23	X-ray diffraction	2.501	N-terminal	B	2014-01-01	Zhao Y., Zhang X. ... Meng L., Zhang J.	10.1021/ml400378e
4L2Y	X-ray diffraction	2.800	N-terminal	B	2014-01-01	Zhao Y., Zhang X. ... Meng L., Zhang J.	10.1021/ml400378e
4OVU	X-ray diffraction	2.960	N-terminal	B	2014-09-03	Miller M.S., Schmidt-Kittler O. ... Vogelstein B., Gabelli S.B.
4OVV	X-ray diffraction	3.500	N-terminal	B	2014-09-03	Miller M.S., Schmidt-Kittler O. ... Vogelstein B., Gabelli S.B.
4WAF	X-ray diffraction	2.390	N-terminal	B	2014-12-31	Barsanti P.A., Aversa R.J. ... Xiao L., Yue Q.	10.1021/ml500353p
4YKN	X-ray diffraction	2.900	N-terminal	A	2015-06-17	Yang H., Medeiros P.F. ... Cuozzo J.W., Evindar G.	10.1021/acsmedchemlett.5b00025
4ZOP	X-ray diffraction	2.620	N-terminal	B	2016-05-18	Fairhurst R.A., Gerspacher M. ... Roehn-Carnemolla E., Luu V.H.
5FI4	X-ray diffraction	2.500	N-terminal	B	2016-02-03	Han W., Menezes D.L. ... Voliva C.F., Pecchi S.	10.1016/j.bmcl.2016.01.003
5GJI	X-ray diffraction	0.900	N-terminal	A	2016-12-14	Inaba S., Numoto N. ... Ito N., Oda M.	10.1074/jbc.M116.755173
5ITD	X-ray diffraction	3.020	N-terminal	B	2016-09-07	Hoegenauer K., Soldermann N. ... Burkhart C., Zecri F.	10.1021/acsmedchemlett.6b00119
5SWG	X-ray diffraction	3.110	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SWO	X-ray diffraction	3.500	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SWP	X-ray diffraction	3.410	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SWR	X-ray diffraction	3.310	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SWT	X-ray diffraction	3.490	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SX8	X-ray diffraction	3.470	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SX9	X-ray diffraction	3.520	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SXB	X-ray diffraction	3.300	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SXC	X-ray diffraction	3.550	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SXD	X-ray diffraction	3.500	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SXE	X-ray diffraction	3.510	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SXI	X-ray diffraction	3.400	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SXK	X-ray diffraction	3.550	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5UK8	X-ray diffraction	2.500	N-terminal	B	2017-06-14	Lu Y., Knapp M. ... Barsanti P., Sim J.	10.1016/j.jmb.2017.04.006
5UKJ	X-ray diffraction	2.800	N-terminal	B	2017-05-10	Lu Y., Knapp M. ... Barsanti P., Sim J.	10.1016/j.jmb.2017.04.006
5UL1	X-ray diffraction	3.000	N-terminal	B	2017-05-10	Lu Y., Knapp M. ... Barsanti P., Sim J.	10.1016/j.jmb.2017.04.006
5XGH	X-ray diffraction	2.970	N-terminal	B	2018-04-25	Yang X., Zhang X. ... Meng L., Zhang J.	10.1038/s41598-017-15260-5
5XGI	X-ray diffraction	2.560	N-terminal	B	2018-04-25	Song K., Yang X., Zhao Y., Jian Z.
5XGJ	X-ray diffraction	2.970	N-terminal	B	2018-04-25	Song K., Yang X., Zhao Y., Jian Z.
6NCT	X-ray diffraction	3.350	N-terminal	B	2019-02-06	Miller M.S., Maheshwari S. ... Jakoncic J., Gabelli S.B.	10.3390/molecules24030496
5SXJ	X-ray diffraction	3.420	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SXF	X-ray diffraction	3.460	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SXA	X-ray diffraction	3.350	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012
5SW8	X-ray diffraction	3.300	N-terminal	B	2017-02-15	Miller M.S., Maheshwari S. ... Vogelstein B., Gabelli S.B.	10.1016/j.bmc.2017.01.012

Protein	Domain	N-term																						bA				bAaA		aA										aAbB				bB								bBbC						bC								bCbD		bD										bDbE		bE			bEbF					bF			bFaB	aB												C-term
																								x50	x51	x52	x53			x42	x43	x44	x45	x46	x47	x48	x49	x50	x51					x45	x46	x47	x48	x49	x50	x51	x52	x49	x50					x47	x48	x49	x50	x51	x52	x53	x54			x47	x48	x49	x50	x51	x52	x53	x54	x55	x56			x48	x49	x50						x48	x49	x50		x46	x47	x48	x49	x50	x51	x52	x53	x54	x55	x56	x57
PIK3R1	N-terminal	P	P	K	P	T	T	V	A	N	N	G	M	N	N	N	M	S	L	Q	D	A	E	W	Y	W	G	D	I	S	R	E	E	V	N	E	K	L	R	D	T	A	D	G	T	F	L	V	R	D	A	S	T	K	M	H	G	D	Y	T	L	T	L	R	K	G	G	N	N	K	L	I	K	I	F	H	R	D	G	K	Y	G	F	S	D	P	-	L	T	F	S	S	V	V	E	L	I	N	H	Y	R	N	E	S	L	A	Q	Y	N	P	K	L	D	V	K	L	L	Y	P	V	S	K	Y	Q	Q	D
PIK3R1	C-terminal	N	T	E	D	Q	Y	S	L	V	E	D	D	E	D	L	P	H	H	D	E	K	T	W	N	V	G	S	S	N	R	N	K	A	E	N	L	L	R	G	K	R	D	G	T	F	L	V	R	E	S	S	K	Q	G	-	-	C	Y	A	C	S	V	V	V	D	G	E	V	K	H	C	V	I	N	K	T	A	T	G	Y	G	F	A	E	P	Y	N	L	Y	S	S	L	K	E	L	V	L	H	Y	Q	H	T	S	L	V	Q	H	N	D	S	L	N	V	T	L	A	Y	P	V	Y	A	Q	Q	R	R

PIK3R1

Sequences

Structures