Protein: PIK3R1
Published: Sept. 29, 2009
Method: X-ray diffraction
Resolution: 2.800
Publication: A frequent kinase domain mutation that changes the interaction between PI3K{alpha} and the membrane.
| Protein | Domain | N-term | bA | bAaA | aA | aAbB | bB | bBbC | bC | bCbD | bD | bDbE | bE | bEbF | bF | bFaB | aB | C-term | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| x50 | x51 | x52 | x53 | x42 | x43 | x44 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x49 | x50 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x48 | x49 | x50 | x48 | x49 | x50 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x57 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PIK3R1 | N-terminal | P | P | K | P | T | T | V | A | N | N | G | M | N | N | N | M | S | L | Q | D | A | E | W | Y | W | G | D | I | S | R | E | E | V | N | E | K | L | R | D | T | A | D | G | T | F | L | V | R | D | A | S | T | K | M | H | G | D | Y | T | L | T | L | R | K | G | G | N | N | K | L | I | K | I | F | H | R | D | G | K | Y | G | F | S | D | P | - | L | T | F | S | S | V | V | E | L | I | N | H | Y | R | N | E | S | L | A | Q | Y | N | P | K | L | D | V | K | L | L | Y | P | V | S | K | Y | Q | Q | D | |
| PIK3R1 | 3HHM_N_B | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | M | S | L | Q | N | A | E | W | Y | W | G | D | I | S | R | E | E | V | N | E | K | L | R | D | T | A | D | G | T | F | L | V | R | D | A | S | T | K | G | - | - | D | Y | T | L | T | L | R | K | G | G | N | N | K | L | I | K | I | F | H | R | D | G | K | Y | G | F | S | D | P | - | L | T | F | S | S | V | V | E | L | I | N | H | Y | R | N | E | S | L | A | Q | Y | N | P | K | L | D | V | K | L | L | Y | P | V | S | K | Y | Q | Q | - | |
| PIK3R1 | C-terminal | N | T | E | D | Q | Y | S | L | V | E | D | D | E | D | L | P | H | H | D | E | K | T | W | N | V | G | S | S | N | R | N | K | A | E | N | L | L | R | G | K | R | D | G | T | F | L | V | R | E | S | S | K | Q | G | - | - | C | Y | A | C | S | V | V | V | D | G | E | V | K | H | C | V | I | N | K | T | A | T | G | Y | G | F | A | E | P | Y | N | L | Y | S | S | L | K | E | L | V | L | H | Y | Q | H | T | S | L | V | Q | H | N | D | S | L | N | V | T | L | A | Y | P | V | Y | A | Q | Q | R | R | |