SH2 (Src Homology 2) domains are modular protein units that establish key protein-protein interactions and are therefore of high interest in drug discovery, particularly for oncological indications. SH2 domains recognize phosphotyrosine (pY)-containing peptide sequences, often as a mechanism for dimer formation, and subsequently regulate a range of cellular processes.

SH2db is a convenient starting point for working with pre-aligned SH2 domain sequences and structures. You can Browse individual entries for proteins, specific structures and AlphaFold models, Search the database by sequence-specific criteria, and download any subset of structures as a Pymol session.

Read more about the general structural features of SH2 domains on the About page.

If you use SH2db in your work, please cite our primary paper:

SH2db, an information system for the SH2 domain.
Bajusz D., Pándy-Szekeres G., Takács Á., de Araujo E.D., Keserű G.M.
Nucleic Acids Research, 2023, 51, W542–W552