Protein: SOCS2
Published: Oct. 13, 2021
Method: X-ray diffraction
Resolution: 3.194
Publication: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
| Protein | Domain | N-term | bA | bAaA | aA | aAbB | bB | bBbC | bC | bCbD | bD | bDbE | bE | bEbF | bF | bFaB | aB | C-term | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| x50 | x51 | x52 | x53 | x42 | x43 | x44 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x49 | x50 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x48 | x49 | x50 | x48 | x49 | x50 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x57 | x58 | x59 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SOCS2 | N-terminal | A | E | E | P | S | P | Q | A | A | R | L | A | K | A | L | R | E | L | G | Q | T | G | W | Y | W | G | S | M | T | V | N | E | A | K | E | K | L | K | E | A | P | E | G | T | F | L | I | R | D | S | S | H | S | D | Y | L | L | T | I | S | V | K | T | S | A | G | P | T | N | L | R | I | E | Y | Q | D | G | K | F | R | L | D | S | I | I | C | V | K | S | K | L | K | Q | F | D | S | V | V | H | L | I | D | Y | Y | V | Q | M | C | K | D | K | R | T | G | P | E | A | P | R | N | G | T | V | H | L | Y | L | T | K | P | |
| SOCS2 | 7M6T_N_A | - | - | - | - | - | - | Q | A | A | R | L | A | K | A | L | R | E | L | G | Q | T | G | W | Y | W | G | S | M | T | V | N | E | A | K | E | K | L | K | E | A | P | E | G | T | F | L | I | R | D | S | S | H | S | D | Y | L | L | T | I | S | V | K | T | S | A | G | P | T | N | L | R | I | E | Y | Q | D | G | K | F | R | L | D | S | I | I | V | A | L | - | - | - | A | A | F | D | S | V | V | H | L | I | D | Y | Y | V | Q | M | C | K | D | K | H | L | Y | L | T | K | P | - | - | - | - | - | - | - | - | - | - | - | - | |