Protein: STAT3
Published: July 22, 2020
Method: X-ray diffraction
Resolution: 2.900
Publication: Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
| Protein | Domain | N-term | bA | bAaA | aA | aAbB | bB | bBbC | bC | bCbD | bD | aB' | aB | C-term | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| x50 | x51 | x52 | x53 | x42 | x43 | x44 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x49 | x50 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x44 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x521 | x53 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| STAT3 | N-terminal | F | W | V | W | L | D | N | I | I | D | L | V | K | K | Y | I | L | A | L | W | N | E | G | Y | I | M | G | F | I | S | K | E | R | E | R | A | I | L | S | T | K | P | P | G | T | F | L | L | R | F | S | E | S | S | K | E | G | G | V | T | F | T | W | V | E | K | D | I | S | G | K | T | Q | I | Q | S | V | E | P | Y | T | K | Q | Q | L | N | N | M | S | F | A | E | I | I | M | G | Y | K | I | M | D | A | T | N | I | L | V | S | P | L | V | Y | L | Y | P | D | I | P | K | E | E | A | F | |
| STAT3 | 6TLC_N_B | F | W | V | W | L | D | N | I | I | D | L | V | K | K | Y | I | L | A | L | W | N | E | G | Y | I | M | G | F | I | S | K | E | R | E | R | A | I | L | S | T | K | P | P | G | T | F | L | L | R | F | S | E | S | S | K | E | G | G | V | T | F | T | W | V | E | K | D | I | S | G | K | T | Q | I | Q | S | V | E | P | Y | T | K | Q | Q | L | N | N | M | S | F | A | E | I | I | M | G | Y | K | I | M | D | A | T | N | I | L | V | S | P | L | V | Y | L | Y | P | D | I | P | K | E | E | A | F | |
| STAT3 | 6TLC_N_A | F | W | V | W | L | D | N | I | I | D | L | V | K | K | Y | I | L | A | L | W | N | E | G | Y | I | M | G | F | I | S | K | E | R | E | R | A | I | L | S | T | K | P | P | G | T | F | L | L | R | F | S | E | S | S | K | E | G | G | V | T | F | T | W | V | E | K | D | I | S | G | K | T | Q | I | Q | S | V | E | P | Y | T | K | Q | Q | L | N | N | M | S | F | A | E | I | I | M | G | Y | K | I | M | D | A | T | N | I | L | V | S | P | L | V | Y | L | Y | P | D | I | P | K | E | E | A | F | |