Protein: FES
Published: June 12, 2019
Method: X-ray diffraction
Resolution: 2.000
Publication: Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.
| Protein | Domain | N-term | bA | bAaA | aA | aAbB | bB | bBbC | bC | bCbD | bD | bDbE | bE | bEbF | bF | bFaB | aB | C-term | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| x50 | x51 | x52 | x53 | x42 | x43 | x44 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x49 | x50 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x48 | x49 | x50 | x48 | x49 | x50 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x57 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| FES | N-terminal | K | F | S | L | P | P | P | L | Q | L | I | P | E | V | Q | K | P | L | H | E | Q | L | W | Y | H | G | A | I | P | R | A | E | V | A | E | L | L | V | H | S | G | D | F | L | V | R | E | S | Q | G | K | Q | E | Y | V | L | S | V | L | W | D | G | L | P | R | H | F | I | I | Q | S | L | D | N | L | Y | R | L | E | G | E | G | F | P | S | I | P | L | L | I | D | H | L | L | S | T | Q | Q | P | L | T | K | K | S | G | V | V | L | H | R | A | V | P | K | D | K | W | V | L | |
| FES | 6JMF_N_A | - | - | - | - | - | - | - | - | - | - | - | - | E | V | Q | K | P | L | H | E | Q | L | W | Y | H | G | A | I | P | R | A | E | V | A | E | L | L | V | H | S | G | D | F | L | V | R | E | S | Q | G | K | Q | E | Y | V | L | S | V | L | W | D | G | L | P | R | H | F | I | I | Q | S | L | D | N | L | Y | R | L | E | G | E | G | F | P | S | I | P | L | L | I | D | H | L | L | S | T | Q | Q | P | L | T | K | K | S | G | V | V | L | H | R | A | V | P | K | D | K | W | V | L | |