Protein: JAK2
Published: Aug. 8, 2018
Method: X-ray diffraction
Resolution: 2.650
Publication: Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.
| Protein | Domain | N-term | bA | bAaA | aA | aAbB | bB | bBbC | bC | bCbD | bD | bDbE | bE | bEbF | bF | bFaB | aB | C-term | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| x50 | x51 | x52 | x53 | x42 | x43 | x44 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x49 | x50 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x48 | x49 | x50 | x48 | x49 | x50 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| JAK2 | N-terminal | A | D | A | H | H | Y | L | C | K | E | V | A | P | P | A | V | L | E | N | I | Q | S | N | C | H | G | P | I | S | M | D | F | A | I | S | K | L | K | K | A | G | N | Q | T | G | L | Y | V | L | R | C | S | P | K | D | F | N | K | Y | F | L | T | F | A | V | E | R | E | N | V | I | E | Y | K | H | C | L | I | T | K | N | E | N | E | E | Y | N | L | S | G | T | K | K | N | F | S | S | L | K | D | L | L | N | C | Y | Q | M | E | T | V | R | S | D | N | I | I | F | Q | F | T | K | C | C | P | P | K | P | K | D | K | S | |
| JAK2 | 6E2Q_N_A | A | D | A | H | H | Y | L | C | K | E | V | A | P | P | A | V | L | E | N | I | Q | S | N | C | H | G | P | I | S | M | D | F | A | I | S | K | L | K | K | A | G | N | Q | T | G | L | Y | V | L | R | C | S | P | K | D | F | N | K | Y | F | L | T | F | A | V | E | R | E | N | V | I | E | Y | K | H | C | L | I | T | K | N | E | N | E | E | Y | N | L | S | G | T | K | K | N | F | S | S | L | K | D | L | L | N | C | Y | Q | M | E | T | V | R | S | D | N | I | I | F | Q | F | T | K | C | C | P | P | K | P | K | D | K | S | |
| JAK2 | 6E2Q_N_B | A | D | A | H | H | Y | L | C | K | E | V | A | P | P | A | V | L | E | N | I | Q | S | N | C | H | G | P | I | S | M | D | F | A | I | S | K | L | K | K | A | G | N | Q | T | G | L | Y | V | L | R | C | S | P | K | D | F | N | K | Y | F | L | T | F | A | V | E | R | E | N | V | I | E | Y | K | H | C | L | I | T | K | N | E | N | E | E | Y | N | L | S | G | T | K | K | N | F | S | S | L | K | D | L | L | N | C | Y | Q | M | E | T | V | R | S | D | N | I | I | F | Q | F | T | K | C | C | P | P | K | P | K | D | K | S | |
| JAK2 | 6E2Q_N_C | A | D | A | H | H | Y | L | C | K | E | V | A | P | P | A | V | L | E | N | I | Q | S | N | C | H | G | P | I | S | M | D | F | A | I | S | K | L | K | K | A | G | N | Q | T | G | L | Y | V | L | R | C | S | P | K | D | F | N | K | Y | F | L | T | F | A | V | - | - | - | - | - | I | E | Y | K | H | C | L | I | T | K | N | E | N | E | E | Y | N | L | S | G | T | K | K | N | F | S | S | L | K | D | L | L | N | C | Y | Q | M | E | T | V | R | S | D | N | I | I | F | Q | F | T | K | C | C | P | P | K | P | K | D | K | S | |
| JAK2 | 6E2Q_N_D | A | D | A | H | H | Y | L | C | K | E | V | A | P | P | A | V | L | E | N | I | Q | S | N | C | H | G | P | I | S | M | D | F | A | I | S | K | L | K | K | - | - | - | - | - | - | - | Y | V | L | R | C | S | P | K | D | F | N | K | Y | F | L | T | F | - | - | - | - | - | - | - | - | - | Y | K | H | C | L | I | T | K | N | E | N | E | E | Y | N | L | S | - | - | - | - | N | F | S | S | L | K | D | L | L | N | C | Y | C | C | P | P | K | P | K | D | K | S | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |