SH2db - JAK2 protein entry

JAK2

Recommended name: Tyrosine-protein kinase JAK2

Gene name: JAK2

No. of SH2 domains: 1

Uniprot: O60674

Sequences

Protein	Domain	N-term																						bA				bAaA		aA													aAbB			bB								bBbC					bC										bCbD		bD												bDbE			bE			bEbF					bF			bFaB	aB									C-term
																								x50	x51	x52	x53			x42	x43	x44	x45	x46	x47	x48	x49	x50	x51	x52	x53	x54				x45	x46	x47	x48	x49	x50	x51	x52	x49	x50				x47	x48	x49	x50	x51	x52	x53	x54	x55	x56			x45	x46	x47	x48	x49	x50	x51	x52	x53	x54	x55	x56				x48	x49	x50						x48	x49	x50		x46	x47	x48	x49	x50	x51	x52	x53	x54
JAK2	N-terminal	A	D	A	H	H	Y	L	C	K	E	V	A	P	P	A	V	L	E	N	I	Q	S	N	C	H	G	P	I	S	M	D	F	A	I	S	K	L	K	K	A	G	N	Q	T	G	L	Y	V	L	R	C	S	P	K	D	F	N	K	Y	F	L	T	F	A	V	E	R	E	N	V	I	E	Y	K	H	C	L	I	T	K	N	E	N	E	E	Y	N	L	S	G	T	K	K	N	F	S	S	L	K	D	L	L	N	C	Y	Q	M	E	T	V	R	S	D	N	I	I	F	Q	F	T	K	C	C	P	P	K	P	K	D	K	S

Structures


PDB	Type	Resolution	Domains	Chains	Publication date	Authors	Reference
O60674-AF	Alphafold	-	N-terminal	A	2022-06-01	-	-
4Z32	X-ray diffraction	3.040	N-terminal	A B C D E F G	2016-06-22	McNally R., Toms A.V., Eck M.J.	10.1371/journal.pone.0156218
6E2P	X-ray diffraction	2.830	N-terminal	A B	2018-08-08	Ferrao R.D., Wallweber H., Lupardus P.J.	10.7554/eLife.38089
6E2Q	X-ray diffraction	2.650	N-terminal	A B C D	2018-08-08	Ferrao R.D., Wallweber H., Lupardus P.J.	10.7554/eLife.38089