Protein: ABL1
Published: April 5, 2017
Method: X-ray diffraction
Resolution: 2.170
Publication: The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
| Protein | Domain | N-term | bA | bAaA | aA | aAbB | bB | bBbC | bC | bCbD | bD | bDbE | bE | bEbF | bF | bFaB | aB | C-term | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| x50 | x51 | x52 | x53 | x42 | x43 | x44 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x49 | x50 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x48 | x49 | x50 | x48 | x49 | x50 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x57 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ABL1 | N-terminal | K | N | G | Q | G | W | V | P | S | N | Y | I | T | P | V | N | S | L | E | K | H | S | W | Y | H | G | P | V | S | R | N | A | A | E | Y | L | L | S | S | G | I | N | G | S | F | L | V | R | E | S | E | S | S | P | G | Q | R | S | I | S | L | R | Y | E | G | R | V | Y | H | Y | R | I | N | T | A | S | D | G | K | L | Y | V | S | S | E | S | R | F | N | T | L | A | E | L | V | H | H | H | S | T | V | A | D | G | L | I | T | T | L | H | Y | P | A | P | K | R | N | K | P | T | V | Y | G | V | |
| ABL1 | 5MO4_N_A | K | N | G | Q | G | W | V | P | S | N | Y | I | T | P | V | N | S | L | E | K | H | S | W | Y | H | G | P | V | S | R | N | A | A | E | Y | L | L | S | S | G | I | N | G | S | F | L | V | R | E | S | E | S | S | P | G | Q | R | S | I | S | L | R | Y | E | G | R | V | Y | H | Y | R | I | N | T | A | S | D | G | K | L | Y | V | S | S | E | S | R | F | N | T | L | A | E | L | V | H | H | H | S | T | V | A | D | G | L | I | T | T | L | H | Y | P | A | P | K | R | N | K | P | T | V | Y | G | V | |