PDB structure 5IBS


Protein: PTPN11

Published: April 13, 2016

Method: X-ray diffraction

Resolution: 2.320

Publication: Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.

Domains: N C

Chains: A B

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Protein Domain N-term bA bAaA aA aAbB bB bBbC bC bCbD bD bDbE bE bEbF bF bFaB aB C-term
x50 x51 x52 x53 x42 x43 x44 x45 x46 x47 x48 x49 x50 x51 x52 x53 x54 x45 x46 x47 x48 x49 x50 x51 x52 x49 x50 x47 x48 x49 x50 x51 x52 x53 x54 x55 x56 x44 x45 x46 x47 x48 x49 x50 x51 x52 x53 x54 x55 x56 x48 x49 x50 x48 x49 x50 x46 x47 x48 x49 x50 x51 x52 x53 x54 x55 x56 x57
PTPN11 N-terminal - - - - - - - - - - - - - - - - - M T S R R W F H P N I T G V E A E N L L L T R G V D G S F L A R P S K S N P G D F T L S V R R - - N G - - - - - - - - A V T H I K I Q N T G D Y Y D L Y G G E K F A T L A E L V Q Y Y M E H H G Q L K E K N G D V I E L K Y P L N C A D P
PTPN11 5IBS_N_A - - - - - - - - - - - - - - - - - - - - R R W F H P N I T G V E A E N L L L T R G V D G S F L A R P - P G - - - D F T L S V R R - - N G - - - - - - - - A V T H I K I Q N T G D Y Y D L Y G G E K F A T L A Q L V Q Y Y M E H G Q L K E V I E L K Y P L N C A D P - - - - -
PTPN11 5IBS_N_B - - - - - - - - - - - - - - - - - - - - R R W F H P N I T G V E A E N L L L T R G V D G S F L A R P S K S N P G D F T L S V R R - - N G - - - - - - - - A V T H I K I Q N T G D Y Y D L Y G G E K F A T L A Q L V Q Y Y M E H H G Q L I E L K Y P L N C A D P - - - - - - -
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PTPN11 C-terminal E K N G D V I E L K Y P L N C A D P T S E R W F H G H L S G K E A E K L L T E K G K H G S F L V R E S Q S H P G D F V L S V R T G D D K G E S N D G K S K V T H V M I R C Q E L K Y D V G G G E R F D S L T D L V E H Y K K N P M V E T L G T V L Q L K Q P L N T T R I N A
PTPN11 5IBS_C_A - - - - E V I E L K Y P L N C A D P T S E R W F H G H L S G K E A E K L L T E K G K H G S F L V R E S Q S H P G D F V L S V R T G D - - - - - - - - K S K V T H V M I R C Q E L K Y D V G G G E R F D S L T D L V E H Y K K N P M V E T L G T V L Q L K Q P L N T T R I N A
PTPN11 5IBS_C_B - - - - - - I E L K Y P L N C A D P T S E R W F H G H L S G K E A E K L L T E K G K H G S F L V R - - H P G - - D F V L S V R T G - - - - - - - - - - - K V T H V M I R C Q E L K Y D V G G G E R F D S L T D L V E H Y K K N P M V E T L G T V L Q L K Q P L N T T R I N A
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