SH2db - PTPN11 protein entry

Protein	Domain	N-term	bA	bAaA	aA	aAbB	bB	bBbC	bC	bCbD	bD	bDbE	bE	bEbF	bF	bFaB	aB	C-term
PTPN11	N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	M	T	S	R	R	W	F	H	P	N	I	T	G	V	E	A	E	N	L	L	L	T	R	G	V	D	G	S	F	L	A	R	P	S	K	S	N	P	G	D	F	T	L	S	V
PTPN11	C-terminal	E	K	N	G	D	V	I	E	L	K	Y	P	L	N	C	A	D	P	T	S	E	R	W	F	H	G	H	L	S	G	K	E	A	E	K	L	L	T	E	K	G	K	H	G	S	F	L	V	R	E	S	Q	S	H	P	G	D	F	V	L	S	V

Structures


PDB	Type	Resolution	Domains	Chains	Publication date	Authors	Reference
Q06124-AF	Alphafold	-	N-terminal C-terminal	A	2022-06-01	-	-
2SHP	X-ray diffraction	2.000	C-terminal N-terminal	A B	1999-02-16	Hof P., Pluskey S. ... Eck M.J., Shoelson S.E.	10.1016/S0092-8674(00)80938-1
4DGP	X-ray diffraction	2.300	C-terminal N-terminal	A	2013-03-06	Yu Z.H., Xu J. ... Liu S., Zhang Z.Y.	10.1074/jbc.M113.450023
4DGX	X-ray diffraction	2.300	C-terminal N-terminal	A	2013-03-06	Yu Z.H., Xu J. ... Liu S., Zhang Z.Y.	10.1074/jbc.M113.450023
4GWF	X-ray diffraction	2.100	C-terminal N-terminal	A B	2013-09-04	Qiu W., Lin A. ... Battaile K., Chirgadze N.Y.
4H1O	X-ray diffraction	2.200	C-terminal N-terminal	A	2013-09-11	Qiu W., Lin A. ... Battaile K., Chirgadze N.Y.
4H34	X-ray diffraction	2.700	C-terminal N-terminal	A	2013-10-02	Qiu W., Lin A. ... Battaile K., Chirgadze N.Y.
4JEG	X-ray diffraction	2.300	C-terminal	A	2013-08-28	Sha F., Gencer E.B. ... Koide S., Hantschel O.	10.1073/pnas.1303640110
4NWF	X-ray diffraction	2.100	C-terminal N-terminal	A B	2014-12-10	Qiu W., Lin A. ... Battalie K., Chirgadze N.Y.
4NWG	X-ray diffraction	2.450	C-terminal N-terminal	A B	2014-12-10	Qiu W., Lin A. ... Battalie K., Chirgadze N.Y.
4OHD	X-ray diffraction	2.700	C-terminal N-terminal	A	2014-09-24	Yu Z.H., Zhang R.Y. ... Liu S., Zhang Z.Y.	10.1021/bi5002695
4OHE	X-ray diffraction	2.506	C-terminal N-terminal	A	2014-09-24	Yu Z.H., Zhang R.Y. ... Liu S., Zhang Z.Y.	10.1021/bi5002695
4OHH	X-ray diffraction	2.700	C-terminal N-terminal	A	2014-09-24	Yu Z.H., Zhang R.Y. ... Liu S., Zhang Z.Y.	10.1021/bi5002695
4OHI	X-ray diffraction	2.200	C-terminal N-terminal	A	2014-09-24	Yu Z.H., Zhang R.Y. ... Liu S., Zhang Z.Y.	10.1021/bi5002695
4OHL	X-ray diffraction	2.400	C-terminal N-terminal	A B	2014-09-24	Yu Z.H., Zhang R.Y. ... Liu S., Zhang Z.Y.	10.1021/bi5002695
5DF6	X-ray diffraction	1.780	C-terminal N-terminal	A	2015-09-23	Liu Y., Lau J. ... Qin S., Min J.	10.1042/BJ20150830
5EHP	X-ray diffraction	1.850	C-terminal N-terminal	A B	2016-07-06	Garcia Fortanet J., Chen C.H. ... Zhang J.H., LaMarche M.J.	10.1021/acs.jmedchem.6b00680
5EHR	X-ray diffraction	1.700	C-terminal N-terminal	A B	2016-06-29	Chen Y.P., LaMarche M.J. ... Stams T., Fortin P.D.	10.1038/nature18621
5I6V	X-ray diffraction	1.870	C-terminal N-terminal	A B	2016-04-13	LaRochelle J.R., Fodor M. ... Acker M.G., Blacklow S.C.	10.1021/acs.biochem.5b01287
5IBM	X-ray diffraction	2.180	C-terminal N-terminal	A B	2016-04-13	LaRochelle J.R., Fodor M. ... Acker M.G., Blacklow S.C.	10.1021/acs.biochem.5b01287
5IBS	X-ray diffraction	2.320	C-terminal N-terminal	A B	2016-04-13	LaRochelle J.R., Fodor M. ... Acker M.G., Blacklow S.C.	10.1021/acs.biochem.5b01287
5X7B	X-ray diffraction	2.450	C-terminal N-terminal	A	2017-09-13	Hayashi T., Senda M. ... Senda T., Hatakeyama M.	10.1016/j.celrep.2017.08.080
5X94	X-ray diffraction	2.600	C-terminal N-terminal	A B	2017-09-13	Hayashi T., Senda M. ... Senda T., Hatakeyama M.	10.1016/j.celrep.2017.08.080
5XZR	X-ray diffraction	2.800	C-terminal N-terminal	A	2017-12-13	Xie J., Si X. ... Liu C., Zhu J.	10.1021/acs.jmedchem.7b01520
6ATD	X-ray diffraction	2.500	C-terminal N-terminal	A B	2018-07-11	Machado L.E.S.F., Critton D.A., Page R., Peti W.	10.1021/acsomega.7b01318
6BMR	X-ray diffraction	2.205	C-terminal N-terminal	A B	2018-01-17	Fodor M., Price E. ... Acker M.G., LaMarche M.J.	10.1021/acschembio.7b00980
6BMU	X-ray diffraction	2.120	C-terminal N-terminal	A B	2018-01-17	Fodor M., Price E. ... Acker M.G., LaMarche M.J.	10.1021/acschembio.7b00980
6BMV	X-ray diffraction	2.053	C-terminal N-terminal	A B	2018-01-17	Fodor M., Price E. ... Acker M.G., LaMarche M.J.	10.1021/acschembio.7b00980
6BMW	X-ray diffraction	2.100	C-terminal N-terminal	A B	2018-01-17	Fodor M., Price E. ... Acker M.G., LaMarche M.J.	10.1021/acschembio.7b00980
6BMX	X-ray diffraction	2.424	C-terminal N-terminal	A B	2018-01-17	Fodor M., Price E. ... Acker M.G., LaMarche M.J.	10.1021/acschembio.7b00980
6BMY	X-ray diffraction	2.090	C-terminal N-terminal	A B	2018-01-17	Fodor M., Price E. ... Acker M.G., LaMarche M.J.	10.1021/acschembio.7b00980
6BN5	X-ray diffraction	2.220	C-terminal N-terminal	A B	2017-12-13	LaRochelle J.R., Fodor M. ... Acker M.G., Blacklow S.C.	10.1016/j.bmc.2017.10.025
6CMP	X-ray diffraction	1.800	C-terminal N-terminal	A B	2018-11-14	Padua R.A.P., Sun Y. ... Otten R., Kern D.	10.1038/s41467-018-06814-w
6CMQ	X-ray diffraction	2.900	C-terminal	A B C D	2018-11-14	Padua R.A.P., Sun Y. ... Otten R., Kern D.	10.1038/s41467-018-06814-w
6CMR	X-ray diffraction	2.210	C-terminal N-terminal	A	2018-11-14	Padua R.A.P., Sun Y. ... Otten R., Kern D.	10.1038/s41467-018-06814-w
6CMS	X-ray diffraction	2.680	C-terminal N-terminal	A	2018-11-14	Padua R.A.P., Sun Y. ... Otten R., Kern D.	10.1038/s41467-018-06814-w
6CRF	X-ray diffraction	2.620	C-terminal N-terminal	A B	2018-11-07	LaRochelle J.R., Fodor M. ... Acker M.G., Blacklow S.C.	10.1038/s41467-018-06823-9
6CRG	X-ray diffraction	2.750	C-terminal N-terminal	A B	2018-11-07	LaRochelle J.R., Fodor M. ... Acker M.G., Blacklow S.C.	10.1038/s41467-018-06823-9
6MD7	X-ray diffraction	1.960	C-terminal N-terminal	A B	2019-02-13	Sarver P., Acker M. ... Yu B., LaMarche M.J.	10.1021/acs.jmedchem.8b01726
6MD9	X-ray diffraction	2.120	C-terminal N-terminal	A B	2019-02-13	Bagdanoff J.T., Chen Z. ... Williams S.L., LaMarche M.J.	10.1021/acs.jmedchem.8b01725
6MDA	X-ray diffraction	2.210	C-terminal N-terminal	A B	2019-02-13	Bagdanoff J.T., Chen Z. ... Williams S.L., LaMarche M.J.	10.1021/acs.jmedchem.8b01725
6MDB	X-ray diffraction	2.340	C-terminal N-terminal	A B	2019-02-13	Sarver P., Acker M. ... Yu B., LaMarche M.J.	10.1021/acs.jmedchem.8b01726
6MDC	X-ray diffraction	2.140	C-terminal N-terminal	A B	2019-02-13	Bagdanoff J.T., Chen Z. ... Williams S.L., LaMarche M.J.	10.1021/acs.jmedchem.8b01725
6MDD	X-ray diffraction	2.050	C-terminal N-terminal	A B	2019-02-13	Bagdanoff J.T., Chen Z. ... Williams S.L., LaMarche M.J.	10.1021/acs.jmedchem.8b01725
3TKZ	X-ray diffraction	1.800	N-terminal	A	2011-10-26	Zhang Y., Zhang J. ... Bell C., Pei D.	10.1021/bi200439v
3TL0	X-ray diffraction	2.050	N-terminal	A	2011-09-28	Zhang Y., Zhang J. ... Bell C., Pei D.	10.1021/bi200439v
4JE4	X-ray diffraction	2.310	N-terminal	A	2013-08-28	Sha F., Gencer E.B. ... Koide S., Hantschel O.	10.1073/pnas.1303640110
4QSY	X-ray diffraction	2.100	N-terminal	A	2015-07-08	Gogl G., Remenyi A.

Protein	Domain	N-term																						bA				bAaA		aA													aAbB		bB								bBbC					bC										bCbD							bD													bDbE		bE			bEbF				bF			bFaB	aB												C-term
																								x50	x51	x52	x53			x42	x43	x44	x45	x46	x47	x48	x49	x50	x51	x52	x53	x54			x45	x46	x47	x48	x49	x50	x51	x52	x49	x50				x47	x48	x49	x50	x51	x52	x53	x54	x55	x56								x44	x45	x46	x47	x48	x49	x50	x51	x52	x53	x54	x55	x56			x48	x49	x50					x48	x49	x50		x46	x47	x48	x49	x50	x51	x52	x53	x54	x55	x56	x57
PTPN11	N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	M	T	S	R	R	W	F	H	P	N	I	T	G	V	E	A	E	N	L	L	L	T	R	G	V	D	G	S	F	L	A	R	P	S	K	S	N	P	G	D	F	T	L	S	V	R	R	-	-	N	G	-	-	-	-	-	-	-	-	A	V	T	H	I	K	I	Q	N	T	G	D	Y	Y	D	L	Y	G	G	E	K	F	A	T	L	A	E	L	V	Q	Y	Y	M	E	H	H	G	Q	L	K	E	K	N	G	D	V	I	E	L	K	Y	P	L	N	C	A	D	P
PTPN11	C-terminal	E	K	N	G	D	V	I	E	L	K	Y	P	L	N	C	A	D	P	T	S	E	R	W	F	H	G	H	L	S	G	K	E	A	E	K	L	L	T	E	K	G	K	H	G	S	F	L	V	R	E	S	Q	S	H	P	G	D	F	V	L	S	V	R	T	G	D	D	K	G	E	S	N	D	G	K	S	K	V	T	H	V	M	I	R	C	Q	E	L	K	Y	D	V	G	G	G	E	R	F	D	S	L	T	D	L	V	E	H	Y	K	K	N	P	M	V	E	T	L	G	T	V	L	Q	L	K	Q	P	L	N	T	T	R	I	N	A

PTPN11

Sequences

Structures