Protein: GRB7
Published: June 15, 2016
Method: X-ray diffraction
Resolution: 2.470
Publication: Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
| Protein | Domain | N-term | bA | bAaA | aA | aAbB | bB | bBbC | bC | bCbD | bD | bDbE | bE | bEbF | bF | bFaB | aB | C-term | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| x50 | x51 | x52 | x53 | x42 | x43 | x44 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x49 | x50 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x57 | x48 | x49 | x50 | x48 | x49 | x50 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x57 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRB7 | N-terminal | R | L | S | L | P | M | P | A | S | G | T | S | L | S | A | A | I | H | R | T | Q | L | W | F | H | G | R | I | S | R | E | E | S | Q | R | L | I | G | Q | Q | G | L | V | D | G | L | F | L | V | R | E | S | Q | R | N | P | Q | G | F | V | L | S | L | C | H | L | Q | K | V | K | H | Y | L | I | L | P | S | E | E | E | G | R | L | Y | F | S | M | D | D | G | Q | T | R | F | T | D | L | L | Q | L | V | E | F | H | Q | L | N | R | G | I | L | P | C | L | L | R | H | C | C | T | R | V | A | L | |
| GRB7 | 5EEL_N_A | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | H | R | T | Q | L | W | F | H | G | R | I | S | R | E | E | S | Q | R | L | I | G | Q | Q | G | L | V | D | G | L | F | L | V | R | E | S | Q | R | N | P | Q | G | F | V | L | S | L | C | H | L | Q | K | V | K | H | Y | L | I | L | P | S | E | E | E | G | R | L | Y | F | S | M | D | D | G | Q | T | R | F | T | D | L | L | Q | L | V | E | F | H | Q | L | N | R | G | I | L | P | C | L | L | R | H | C | C | T | R | - | - | - | |
| GRB7 | 5EEL_N_B | - | - | - | - | - | - | - | - | - | - | - | - | L | S | A | A | I | H | R | T | Q | L | W | F | H | G | R | I | S | R | E | E | S | Q | R | L | I | G | Q | Q | G | L | V | D | G | L | F | L | V | R | E | S | Q | R | N | P | Q | G | F | V | L | S | L | C | H | L | Q | K | V | K | H | Y | L | I | L | P | S | E | E | E | G | R | L | Y | F | S | M | D | D | G | Q | T | R | F | T | D | L | L | Q | L | V | E | F | H | Q | L | N | R | G | I | L | P | C | L | L | R | H | C | C | T | R | - | - | - | |
| GRB7 | 5EEL_N_C | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | R | T | Q | L | W | F | H | G | R | I | S | R | E | E | S | Q | R | L | I | G | Q | Q | G | L | V | D | G | L | F | L | V | R | E | S | Q | R | N | P | Q | G | F | V | L | S | L | C | H | L | Q | K | V | K | H | Y | L | I | L | P | S | E | E | E | G | R | L | Y | F | S | M | D | D | G | Q | T | R | F | T | D | L | L | Q | L | V | E | F | H | Q | L | N | R | G | I | L | P | C | L | L | R | H | C | C | T | R | V | A | - | |
| GRB7 | 5EEL_N_D | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | T | Q | L | W | F | H | G | R | I | S | R | E | E | S | Q | R | L | I | G | Q | Q | G | L | V | D | G | L | F | L | V | R | E | S | Q | R | N | P | Q | G | F | V | L | S | L | C | H | L | Q | K | V | K | H | Y | L | I | L | P | S | E | E | E | G | R | L | Y | F | S | M | D | D | G | Q | T | R | F | T | D | L | L | Q | L | V | E | F | H | Q | L | N | R | G | I | L | P | C | L | L | R | H | C | C | T | R | - | - | - | |
| GRB7 | 5EEL_N_E | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | Q | L | W | F | H | G | R | I | S | R | E | E | S | Q | R | L | I | G | Q | Q | G | L | V | D | G | L | F | L | V | R | E | S | Q | R | N | P | Q | G | F | V | L | S | L | C | H | L | Q | K | V | K | H | Y | L | I | L | P | S | E | E | E | G | R | L | Y | F | S | M | D | D | G | Q | T | R | F | T | D | L | L | Q | L | V | E | F | H | Q | L | N | R | G | I | L | P | C | L | L | R | H | C | C | T | R | V | - | - | |
| GRB7 | 5EEL_N_F | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | R | T | Q | L | W | F | H | G | R | I | S | R | E | E | S | Q | R | L | I | G | Q | Q | G | L | V | D | G | L | F | L | V | R | E | S | Q | R | N | P | Q | G | F | V | L | S | L | C | H | L | Q | K | V | K | H | Y | L | I | L | P | S | E | E | E | G | R | L | Y | F | S | M | D | D | G | Q | T | R | F | T | D | L | L | Q | L | V | E | F | H | Q | L | N | R | G | I | L | P | C | L | L | R | H | C | C | T | R | V | - | - | |