SH2db - 2RMX structure entry

PDB structure 2RMX

Protein: PTPN6

Published: Dec. 2, 2008

Method: Solution NMR

Publication: Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1 (to be published)

Protein	Domain	N-term																						bA				bAaA		aA													aAbB		bB								bBbC					bC								bCbD											bD										bDbE		bE			bEbF				bF			bFaB	aB												C-term

																								x50	x51	x52	x53			x42	x43	x44	x45	x46	x47	x48	x49	x50	x51	x52	x53	x54			x45	x46	x47	x48	x49	x50	x51	x52	x49	x50				x47	x48	x49	x50	x51	x52	x53	x54												x47	x48	x49	x50	x51	x52	x53	x54	x55	x56			x48	x49	x50					x48	x49	x50		x46	x47	x48	x49	x50	x51	x52	x53	x54	x55	x56	x57
PTPN6	N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	M	V	R	W	F	H	R	D	L	S	G	L	D	A	E	T	L	L	K	G	R	G	V	H	G	S	F	L	A	R	P	S	R	K	N	Q	G	D	F	S	L	S	V	R	V	G	D	-	-	-	-	-	-	-	-	-	Q	V	T	H	I	R	I	Q	N	S	G	D	F	Y	D	L	Y	G	G	E	K	F	A	T	L	T	E	L	V	E	Y	Y	T	Q	Q	Q	G	V	L	Q	D	R	D	G	T	I	I	H	L	K	Y	P	L	N	C	S	D	P
PTPN6	C-terminal	D	R	D	G	T	I	I	H	L	K	Y	P	L	N	C	S	D	P	T	S	E	R	W	Y	H	G	H	M	S	G	G	Q	A	E	T	L	L	Q	A	K	G	E	P	W	T	F	L	V	R	E	S	L	S	Q	P	G	D	F	V	L	S	V	L	S	D	Q	P	K	A	G	P	G	S	P	L	R	V	T	H	I	K	V	M	C	E	G	G	R	Y	T	V	G	G	L	E	T	F	D	S	L	T	D	L	V	E	H	F	K	K	T	G	I	E	E	A	S	G	A	F	V	Y	L	R	Q	P	Y	Y	A	T	R	V	N	A
PTPN6	2RMX_C_A	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	G	S	S	G	S	S	G	W	Y	H	G	H	M	S	G	G	Q	A	E	T	L	L	Q	A	K	G	E	P	W	T	F	L	V	R	E	S	L	S	Q	P	G	D	F	V	L	S	V	L	S	D	Q	P	K	A	G	P	G	S	P	L	R	V	T	H	I	K	V	M	C	E	G	G	R	Y	T	V	G	G	L	E	T	F	D	S	L	T	D	L	V	E	H	F	K	K	T	G	I	E	E	A	S	G	A	F	V	Y	L	R	Q	P	Y	Y	S	G	P	S	S	G

PDB structure 2RMX

Domains: N C

Chains: A