SH2db - SYK protein entry

SYK

Recommended name: Tyrosine-protein kinase SYK

Gene name: SYK

No. of SH2 domains: 2

Uniprot: P43405

Sequences

Protein	Domain	N-term																						bA				bAaA		aA											aAbB					bB								bBbC					bC								bCbD		bD										bDbE			bE			bEbF				bF			bFaB	aB												C-term
																								x50	x51	x52	x53			x42	x43	x44	x45	x46	x47	x48	x49	x50	x51	x52						x45	x46	x47	x48	x49	x50	x51	x52	x49	x50				x47	x48	x49	x50	x51	x52	x53	x54			x47	x48	x49	x50	x51	x52	x53	x54	x55	x56				x48	x49	x50					x48	x49	x50		x46	x47	x48	x49	x50	x51	x52	x53	x54	x55	x56	x57
SYK	N-terminal	-	-	-	-	-	-	-	-	M	A	S	S	G	M	A	D	S	A	N	H	L	P	F	F	F	G	N	I	T	R	E	E	A	E	D	Y	L	V	Q	G	G	M	S	D	G	L	Y	L	L	R	Q	S	R	N	Y	L	G	G	F	A	L	S	V	A	H	G	R	K	A	H	H	Y	T	I	E	R	E	L	N	G	T	Y	A	I	A	G	G	R	T	H	A	S	P	A	D	L	C	H	Y	H	S	Q	E	S	D	G	L	V	C	L	L	K	K	P	F	N	R	P	Q	G	V	Q	P	K	T	G
SYK	C-terminal	A	I	I	S	Q	K	P	Q	L	E	K	L	I	A	T	T	A	H	E	K	M	P	W	F	H	G	K	I	S	R	E	E	S	E	Q	I	V	L	I	G	S	K	T	N	G	K	F	L	I	R	A	R	D	N	N	G	-	S	Y	A	L	C	L	L	H	E	G	K	V	L	H	Y	R	I	D	K	D	K	T	G	K	L	S	I	P	E	G	K	K	F	D	T	L	W	Q	L	V	E	H	Y	S	Y	K	A	D	G	L	L	R	V	L	T	V	P	C	Q	K	I	G	T	Q	G	N	V	N	F

Structures


PDB	Type	Resolution	Domains	Chains	Publication date	Authors	Reference
P43405-AF	Alphafold	-	N-terminal C-terminal	A	2022-06-01	-	-
1A81	X-ray diffraction	3.000	C-terminal N-terminal	A C E G I K	1998-10-21	Futterer K., Wong J. ... Chan A.C., Waksman G.	10.1006/jmbi.1998.1964
4FL2	X-ray diffraction	2.190	C-terminal N-terminal	A	2012-11-28	Gradler U., Schwarz D. ... Muller-Pompalla D., Wegener A.	10.1016/j.jmb.2012.11.007
4FL3	X-ray diffraction	1.900	C-terminal N-terminal	A	2012-11-28	Gradler U., Schwarz D. ... Muller-Pompalla D., Wegener A.	10.1016/j.jmb.2012.11.007
1CSY	Solution NMR	None	C-terminal	A	1996-11-08	Narula S.S., Yuan R.W. ... Karas J.L., Dalgarno D.C.	10.1016/S0969-2126(01)00242-8
1CSZ	Solution NMR	None	C-terminal	A	1996-11-08	Narula S.S., Yuan R.W. ... Karas J.L., Dalgarno D.C.	10.1016/S0969-2126(01)00242-8