Protein: HCK
Published: May 1, 2013
Method: X-ray diffraction
Resolution: 2.747
Publication: A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo
| Protein | Domain | N-term | bA | bAaA | aA | aAbB | bB | bBbC | bC | bCbD | bD | bDbE | bE | bEbF | bF | bFaB | aB | C-term | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| x50 | x51 | x52 | x53 | x42 | x43 | x44 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x49 | x50 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x44 | x45 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x48 | x49 | x50 | x48 | x49 | x50 | x46 | x47 | x48 | x49 | x50 | x51 | x52 | x53 | x54 | x55 | x56 | x57 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HCK | N-terminal | T | R | K | E | G | Y | I | P | S | N | Y | V | A | R | V | D | S | L | E | T | E | E | W | F | F | K | G | I | S | R | K | D | A | E | R | Q | L | L | A | P | G | N | M | L | G | S | F | M | I | R | D | S | E | T | T | K | G | S | Y | S | L | S | V | R | D | Y | D | P | R | Q | G | D | T | V | K | H | Y | K | I | R | T | L | D | N | G | G | F | Y | I | S | P | R | S | T | F | S | T | L | Q | E | L | V | D | H | Y | K | K | G | N | D | G | L | C | Q | K | L | S | V | P | C | M | S | S | K | P | Q | K | P | W | E | K | |
| HCK | 3VS4_N_A | T | R | K | E | G | Y | I | P | S | N | Y | V | A | R | V | D | S | L | E | T | E | E | W | F | F | K | G | I | S | R | K | D | A | E | R | Q | L | L | A | P | G | N | M | L | G | S | F | M | I | R | D | S | E | T | T | K | G | S | Y | S | L | S | V | R | D | Y | D | P | R | Q | G | D | T | V | K | H | Y | K | I | R | - | - | - | - | - | - | F | Y | I | S | P | R | S | T | F | S | T | L | Q | E | L | V | D | H | Y | K | K | G | N | D | G | L | C | Q | K | L | S | V | P | C | M | S | S | K | P | Q | K | - | - | - | - | |
| HCK | 3VS4_N_B | T | R | K | E | G | Y | I | P | S | N | Y | V | A | R | V | D | S | L | E | T | E | E | W | F | F | K | G | I | S | R | K | D | A | E | R | Q | L | L | A | P | G | N | M | L | G | S | F | M | I | R | D | S | E | T | T | K | G | S | Y | S | L | S | V | R | D | Y | D | P | R | Q | G | D | T | V | K | H | Y | K | I | R | T | L | D | N | G | G | F | Y | I | S | P | R | S | T | F | S | T | L | Q | E | L | V | D | H | Y | K | K | G | N | D | G | L | C | Q | K | L | S | V | P | C | M | S | S | K | P | Q | K | - | - | - | - | |