SH2db - 1CJ1 structure entry

PDB structure 1CJ1

Protein: GRB2

Published: Dec. 22, 1999

Method: X-ray diffraction

Resolution: 3.000

Publication: Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.

Domains: N

Chains: A B C D E F G H I J K L

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	Protein	Domain	N-term																						bA				bAaA		aA												aAbB			bB								bBbC					bC								bCbD		bD										bDbE			bE			bEbF			bF			bFaB	aB												C-term

																									x50	x51	x52	x53			x42	x43	x44	x45	x46	x47	x48	x49	x50	x51	x52	x53				x45	x46	x47	x48	x49	x50	x51	x52	x49	x50				x47	x48	x49	x50	x51	x52	x53	x54			x47	x48	x49	x50	x51	x52	x53	x54	x55	x56				x48	x49	x50				x48	x49	x50		x46	x47	x48	x49	x50	x51	x52	x53	x54	x55	x56	x57
	GRB2	N-terminal	K	A	E	L	N	G	K	D	G	F	I	P	K	N	Y	I	E	M	K	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	Q	V	P	Q	Q	P	T	Y	V
	GRB2	1CJ1_N_A	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_B	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_C	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_D	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_E	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_F	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_G	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_H	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_I	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_J	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_K	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-
	GRB2	1CJ1_N_L	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	P	H	P	W	F	F	G	K	I	P	R	A	K	A	E	E	M	L	S	K	Q	R	H	D	G	A	F	L	I	R	E	S	E	S	A	P	G	D	F	S	L	S	V	K	F	G	N	D	V	Q	H	F	K	V	L	R	D	G	A	G	K	Y	F	L	W	V	V	K	F	N	S	L	N	E	L	V	D	Y	H	R	S	T	S	V	S	R	N	Q	Q	I	F	L	R	D	I	E	-	-	-	-	-	-	-	-	-